Napoli vs Eintracht Frankfurt prediction 04.11.2025 | UEFA Champions League

Napoli’s performances in Europe and Serie A have been a tale of contrasts. Domestically, Antonio Conte’s side are currently in pole position to defend their league title, sitting top of the Serie A standings with 22 points from 10 matches. However, their campaign in Europe’s elite competition has been far less convincing. The Azzurri have recorded just one win from their opening three group fixtures and sit only one point above 25th-placed Juventus, who are currently outside the qualification zone.

Their most recent Champions League outing was a major setback - a 6-2 defeat to Eredivisie side PSV Eindhoven - a result that raised questions about their defensive resilience. Nevertheless, Napoli responded positively in domestic competition, earning seven points from a possible nine in their last three Serie A games. Despite that rebound, their defensive record in Europe remains concerning, particularly away from home, where they have conceded an average of 3.0 goals per match.

In terms of team news, injuries continue to affect Conte’s selection options. Billy Gilmour lasted just 38 minutes in the goalless draw against Como at the weekend and is considered doubtful for Tuesday’s clash. Meanwhile, Kevin De Bruyne, Matteo Politano, and Alex Meret are all ruled out, limiting Napoli’s depth in both midfield and attack.

Frankfurt’s form has been inconsistent. After demolishing Galatasaray 5-1 on the opening matchday of the 2025/26 Champions League campaign, they suffered back-to-back 5-1 defeats to Atlético Madrid and Liverpool. Their domestic performances have also lacked stability - a 1-1 draw with Heidenheim at the weekend followed their DFB-Pokal elimination on penalties to Borussia Dortmund.

Defensively, Frankfurt have struggled to maintain concentration over 90 minutes. They have kept just two clean sheets in 14 matches across all competitions this season, exposing weaknesses in organisation and chance prevention. However, their attacking output has been one of the few bright spots. In the Bundesliga, they average 2.4 goals per game, and in Europe, they have already scored seven times in three group-stage matches - showing their ability to create and convert chances despite defensive frailties.

According to Sofascore, only Elias Baum and Oscar Højlund are unavailable ahead of Tuesday’s encounter, meaning Dino Toppmöller will otherwise have a full squad to choose from.