MLS Predictions and Tips

Thirty teams started the battle for the MLS Cup in February 2025, with the LA Galaxy being the defending champions. The Californians are the most celebrated club in the league, winning their sixth title in 2024. There are 34 regular-season games for each team before the playoffs begin, and the previous campaigns proved that even the biggest underdogs can do well when the real battle for the MLS Cup begins.

For instance, the New York Red Bulls were only the seventh seed in the Eastern Conference in 2024, yet they made it to the final and just narrowly lost to the LA Galaxy. Make sure to bookmark this page, as we are always ready to provide you with expert MLS betting tips throughout the season, from the first round of games in February to the deciding match in December.

Inter Miami are the heavy favourites for the 2025 MLS Cup, led by the legendary Lionel Messi. With an exceptional squad depth, including star players like Jordi Alba, Luis Suárez, and Sergio Busquets, they have the experience and tactical flexibility to dominate. Miami's attacking prowess looks second to none.

FC Cincinnati's well-balanced play makes them another top contender. With a potent attack led by Evander and Yuya Kubo, combined with a solid defence, they have everything required for success. Cincinnati's rapid growth and consistency are very hard to come by.

Vancouver Whitecaps FC are another well-balanced team. Strong performances from players like Brian White and Ryan Gauld have bolstered their attack, while defensive toughness makes them tough to break down. Their stability and determination could see them lift the MLS Cup this year.

LAFC are a formidable force thanks to a blend of experienced players and youthful energy. We all know that tactical discipline and playoff experience can go a long way. Besides, they have a fantastic goalkeeper in Frenchman Hugo Lloris.

The Philadelphia Union, coached by South African Bradley Carnell, have a great leader in Tai Baribo and a robust defence. Their depth and resilience, along with an acute tactical approach, can lead to great things this year.

Our USA league prediction: Inter Miami will finally win their first MLS Cup in 2025.

Major League Soccer – odds on the favourites

The table below lists the top-10 contenders to win the MLS Cup ahead of the new campaign (15.02.2025), along with the MLS winner odds. Curiously, the defending champions, the Los Angeles Galaxy, were only the fifth favourite, while Inter Miami CF were the team to beat according to the bookies.

Teams are divided into the Eastern and Western Conferences, playing 34 games in the regular season. With 30 teams in 2025, each club plays home and away against other teams from their conference, and six more games against sides from the opposite conference. At the end of the regular season, the team with the most points gets the Supporters' Shield and home-field advantage throughout the playoffs.

The regular season is followed by the MLS Cup playoffs, with eighteen teams participating. The eighth and ninth-placed teams in each conference play against each other in a single-elimination play-in match. Then it's time for a best-of-three round, followed by single-elimination rounds in conference semifinals and finals. The winners of both conferences take part in the final. The four best teams of the regular season qualify for the CONCACAF Champions Cup along with the MLS Cup holders. With 500+ games in a single campaign, there will be plenty of helpful MLS predictions here throughout the season.

Which teams are in the MLS?

Major League Soccer underwent another expansion ahead of the 2025 season, as San Diego FC was added to the Western Conference. These are the current MLS clubs:

Eastern Conference: Atlanta United FC, Charlotte FC, Chicago Fire FC, FC Cincinnati, Columbus Crew, D.C. United, Inter Miami CF, CF Montréal, Nashville SC, New England Revolution, New York City FC, New York Red Bulls, Orlando City SC, Philadelphia Union, Toronto FC.

Western Conference: Austin FC, Colorado Rapids, FC Dallas, Houston Dynamo FC, LA Galaxy, Los Angeles FC, Minnesota United FC, Portland Timbers, Real Salt Lake, San Diego FC, San Jose Earthquakes, Seattle Sounders FC, Sporting Kansas City, St. Louis City SC, Vancouver Whitecaps FC.

We are thoroughly examining the betting options available when preparing our MLS football tips. Some of the betting markets we always pay close attention to are:

• 1x2: A classic betting market, where you choose whether it'll be a victory for the home team, away team, or the match will end in a draw. Very straightforward, making it popular among casual bettors.

• Both teams to score: MLS games are often very high-scoring, with strong attacking players, so BTTS is a feasible option for those who expect both teams to find the net.

• Over 2.5 goals: MLS is known for fast-paced and attacking football, and it's wise to go for this bet when expecting an exciting game. In 2024, 1,552 goals were scored in 493 MLS matches, averaging 3.15 goals per game.

• Correct score: A riskier bet, but with much higher odds. MLS matches, at times, are very unpredictable, so this bet offers high rewards for those who can accurately gauge the outcome.

• Double chance: This bet covers two of the three possible outcomes. It's a safer option for bettors who want to increase their chances of winning, albeit at much lower odds.

This page is dedicated solely to USA MLS predictions, and our experts work steadily to identify the best betting opportunities by analysing upcoming matches at the highest level of the United States soccer league system. In addition to this, we also provide coverage of numerous other leagues and tournaments, including:

• EPL predictions

• Scottish Premiership predictions

• Brazil Serie A predictions