Bayer Leverkusen vs Paris Saint-Germain prediction 21.10.2025 | Champions League

A run of three consecutive wins has lifted Bayer Leverkusen up to fifth in the Bundesliga standings, following a slow start that saw them secure just one victory in their first four matches.

Die Werkself celebrated their return from the international break with a 4-3 victory against Mainz on Saturday afternoon. They dominated the game at times, leading 2-0 after 24 minutes, but their defence let them down again.

Kasper Hjulmand’s side have kept only one clean sheet in their last nine matches and may struggle against Paris Saint-Germain, who are deadly in front of goal.

However, Leverkusen fans will be encouraged by the fact that their team avoided defeat in 12 of their last 14 European games at the BayArena. Martin Terrier, Exequiel Palacios, Axel Tapé and Nathan Tella are all ruled out with injuries, while Sarco, Terrier, Palacios and Hofmann are not eligible to compete in Europe.

PSG have struggled since their run of six consecutive league wins came to an end against Marseille in Ligue 1 at the end of last month.

Although Les Parisiens secured victories against Barcelona in Europe and Auxerre in their last four matches, draws against Lille and Strasbourg have seen them drop to second in the league standings.

Nevertheless, Luis Enrique will be motivated by the fact that his PSG side won each of their last five Champions League matches, scoring 14 goals and also kept three clean sheets.

Ballon d'Or winner Ousmane Dembélé remains sidelined for the visitors due to injury, but the likes of Désiré Doué and Khvicha Kvaratskhelia are available after recovering from their issues.