Barcelona vs Olympiacos Prediction 21.10.2025 | UEFA Champions League

Barcelona suffered a couple of heavy blows before heading into the two-week international break, first falling 2-1 to UCL title-holders PSG on Catalan soil and then enduring a painful 4-1 hammering at the hands of Sevilla in Andalusia.

Fortunately, Blaugrana managed to recover and get back on the winning track, but their performance was far from thrilling, as they had to dig deep to secure a last-gasp 2-1 triumph in the Catalan derby against Girona over the weekend.

Barcelona boss Hansi Flick cannot be pleased with the way his team’s backline has been performing in recent times, as he has overseen them go five straight matches without a clean sheet, conceding a worrying nine goals in that period.

The Catalan giants are facing a host of absences, with Joan Garcia, Marc Andre ter Stegen, Gavi, Dani Olmo, Raphinha, and Robert Lewandowski all definitely out, while Ferran Torres remains doubtful.

Like Tuesday’s hosts, Olympiacos also suffered their first defeats of the season in the last two matches before the international break, slipping 2-0 against Arsenal in the second round of the Champions League and falling 2-1 to PAOK in league action.

However, the Red-Whites ended their run of back-to-back competitive setbacks over the weekend, cruising to a comfortable 2-0 win at AEL Larissa and successfully boosting their confidence ahead of their return to Champions League duty.

Unfortunately, Olympiacos’ chances of causing an upset on Tuesday night and becoming the first Greek team to win in Spain look almost nonexistent, given the disastrous form they have shown on the road in this competition, having lost each of their previous 11 UCL trips.

Captain Panagiotis Retsos missed the October international call-up due to injury, but he is expected to be fit for the clash against Barcelona, alongside Brazilian right-back Rodinei, who recently struggled with calf issues.