Arsenal vs Atletico Madrid prediction 21.10.2025 | UEFA Champions League

Arsenal enter this fixture riding a strong domestic run. They currently sit at the top of the Premier League table with 19 points and have won three consecutive league matches in recent weeks. Even more impressively, their overall form across all competitions has been excellent - Arsenal are unbeaten in eight straight matches, with their only dropped points coming in a 1-1 draw against Manchester City. 

At home, their attacking output has been even stronger, with data showing they average around 2.6 goals per game in Champions League fixtures at the Emirates. Defensively, Arsenal have also shown remarkable solidity, conceding an average of just 0.4 goals per match in their last five outings and keeping three consecutive clean sheets across all competitions. 

However, manager Mikel Arteta faces a growing injury list. Captain Martin Ødegaard has been ruled out with a medial collateral ligament injury and will miss this match.

Atlético come into the match with mixed form overall this season, though recent performances mark a clear improvement compared to a difficult August and September. Following their away defeat to Liverpool in the Champions League, Diego Simeone’s men have gone unbeaten in six consecutive matches across all competitions, recording emphatic victories during that run - including a stunning 5-2 win over Real Madrid and a 5-1 triumph against Eintracht Frankfurt in the Champions League. 

Statistically, Atlético have averaged 2.7 goals per game over their last six matches but have also conceded in every one of them. Both teams have scored (BTTS) in each of those six fixtures, underlining their attacking strength and defensive vulnerability. Their defensive average of 1.4 goals conceded per match in recent weeks highlights potential issues away from home.