2025 US Open Betting Preview – Odds, Favourites & Predictions (ATP & WTA)

The last Grand Slam event of the year will start on August 24, 2025, and MightyTips' pundits preview the tournament at the USTA Billie Jean King National Tennis Center in New York. In this article, we'll have a look at the US Open 2025 odds on the main favourites, according to the bookmakers, and talk about some of the top contenders, including their recent form and pedigree.

Jannik Sinner and Aryna Sabalenka will try to defend their titles, while the top story is probably the return of Venus Williams. The 45-year-old, US Open champion in 2000 and 2001, played just three matches this year, and got a very tough draw in the first round against the 11th seed Karolína Muchová.

These are the top seven favourites of the US Open 2025, along with their odds. Sinner looks like the man to beat, which shouldn't be a surprise, but Carlos Alcaraz is right behind him. Last year's finalist, Taylor Fritz, is only seventh in the list.

Favourites to win the men’s 2025 US Open

Given that Sinner and Alcaraz are the only Grand Slam winners this year (and played against each other in two of the three finals), it's hard to see someone challenging these two. However, Novak Djokovic, who holds the record with 24 majors, will obviously have other ideas.

Jannik Sinner

The world number 1 has had a stellar year, winning the Australian Open and claiming his first Wimbledon title. Sinner already has four Grand Slam victories and became the youngest man to reach four consecutive major finals. His hard-court form has been brilliant, with a 26-match winning streak that ties a modern-era record. Sinner had to retire from the Cincinnati Open final due to illness, though, and that was just six days ahead of the US Open. His camp already stated that he'll fully recover in time for New York. If healthy, the Italian is an undoubted favourite and could consolidate his dominance by winning a second straight US Open and extending his legacy. One last thing to note, Sinner must do better than Alcaraz to stay as number 1 in the ATP rankings.

Carlos Alcaraz

The Spaniard, world No. 2 and 2022 US Open champion, arrives with strong momentum. He recently won Roland Garros and captured the Cincinnati title, thanks to a walkover against Sinner, adding another Masters crown. Alcaraz compiled an impressive 24-match winning streak in 2025 and is a very versatile player, excellent on all surfaces. He has a tough draw, playing against American Reilly Opelka in the first round, while his route to the final might include battles with Daniil Medvedev, Ben Shelton, Casper Ruud, and, possibly, Djokovic. Alcaraz's ability to improve in big moments is unquestionable, and his previous triumph at Flushing Meadows proves that he thrives in this atmosphere. The path is challenging, yet Alcaraz remains one of the few players with both the weapons and mentality to win the title.

Novak Djokovic

Despite being slightly past his peak, Djokovic remains a top contender at the US Open. He hasn't played since June, following a Wimbledon semifinal loss to Sinner. Nole is navigating a tough draw that features early tests against American stars Learner Tien, Sebastian Korda, and Alex Michelsen, with a looming match against Holger Rune in the fourth round. Yet consistency in Grand Slams for 15+ years means he can't be discounted. Djokovic is ever-dangerous, but his current form remains a mystery. The Serbian still carries unmatched experience, tactical brilliance, and a proven ability to peak when it matters. While expectations are lower compared to previous years, a deep run is possible. If he finds rhythm early and avoids exhausting five-set matches, Djokovic remains a dark horse in New York City.

Alexander Zverev

Zverev is a decent outside pick at the US Open. He begins the tournament against Alejandro Tabilo and, if all goes to plan, might meet Sinner in the semifinals. Yet his summer form has been shaky: at Wimbledon, he was knocked out in the first round, and struggled physically in Cincinnati, raising questions about his match fitness. When Zverev's serve and baseline consistency click, he definitely can trouble anyone, especially on hard courts. The German has previously come close to US Open glory, narrowly losing to Dominic Thiem in the 2020 final. If he can rediscover confidence and navigate the early stages without too much drama, Zverev has the potential to spring a surprise.

ATP US Open winner prediction

While the odds are not ideal for such a long-term bet, we can't go against Sinner and his fantastic form. If he managed to recover from the illness fully, which we believe he did, the first real test for the Italian should come at a quarterfinal or even semifinal stage. We'd love to find better odds than 2.10, but it is what it is. Remember that we are trying to win, not bet on the most enormous odds possible.

The table below indicates the top 7 contenders in women's singles ahead of the US Open 2025. Curiously, the world number one and the defending champion, Aryna Sabalenka, is the second favourite, below Iga Swiatek. Last year's finalist, Jessica Pegula, is only 14th in this list, at 26.00. Venus Williams to win can be had at 501.00.

Favourites to win women’s 2025 US Open

Just as in men’s singles, this appears to be a 2-horse race. However, women’s tennis is a completely different sport with upsets coming thick and fast. Just remember Madison Keys winning earlier this year at the Australian Open, or unseeded Markéta Vondroušová claiming the 2023 Wimbledon title.

Iga Świątek

Świątek arrives in New York with renewed confidence after winning Wimbledon and following it up with another big title in Cincinnati. Those victories reaffirm her as one of the most dangerous players on the WTA tour, particularly when her confidence and precision align. Her game, built around consistency, heavy topspin, and relentless stamina, translates well to playing on hard courts. Świątek already claimed the US Open title in 2022, and her improved serving and tactical adjustments should bear more fruit. She's now entering the event with momentum and a renewed belief that she can conquer all surfaces. If she maintains her current level, Świątek has every chance of lifting the trophy in New York, which would also return her to the top spot in the WTA Tour. For that, she would also need Sabalenka to lose before the last four.

Aryna Sabalenka

Sabalenka played just one tournament since losing in Wimbledon's final, exiting the Cincinnati Open in the fourth round after losing to Elena Rybakina in straight sets. Yet she has enjoyed consistent results in 2025, reaching the finals of the Australian Open and Roland Garros while showcasing improved mental resilience and shot tolerance, which were once viewed as her weak sides. A commanding presence on hard courts, combined with her aggressive baseline game, makes her a formidable opponent in New York. She excels under the spotlight, and her ability to dictate points with powerful serving and relentless ball-striking is tough to counter. Sabalenka will need to stay sharp through potentially tricky early matches and maintain composure against rivals who know how to exploit her weaknesses. If she maintains focus, her title defence looks promising.

Coco Gauff

Coco Gauff remains one of the most exciting young stars on the WTA Tour, and the US Open is a tournament that often brings out her best. Her explosive athleticism and ability to turn defence into offence make her a nightmare opponent on hard courts - just remember the way she won the US Open in 2023. Gauff's home-court advantage and crowd support could lead to great things. Her summer form has been mixed, though, as she won only five of the last nine matches after triumphing at Roland Garros. Much will depend on her consistency in service games, which has been a vulnerability. One last thing to note, she has changed her coach just days before the event, and that's never a good sign. Moreover, this makes Gauff a player to bet against.

Mirra Andreeva

The teenage prodigy is rapidly establishing herself as one of the most exciting young players in women's tennis. At just 18, Andreeva has already proven her ability to compete with the favourites, displaying solid composure, variety, and tactical intelligence well beyond her years. She is still considered a developing player rather than a title contender, but her rise through the ranks has been superimpressive. Ahead of the US Open, her form has been steady, with encouraging performances on hard courts earlier in the season. While expectations are modest compared to established stars, she has the potential to make headlines with a breakthrough. Andreeva has a favourable draw that could see her reach at least the second week.

WTA US Open winner prediction

If we were to choose between Sabalenka and Swiatek, we’d go with the latter. Yet the unpredictable nature of women’s tennis and the odds of just 3.50 for the Pole to win make us look for other options. Let’s say it this way - while it’s a very bold prediction which you definitely shouldn’t follow, betting half a unit on Elena Rybakina to win at 12.00 might be worth thinking about.