LA Rams vs Jacksonville Jaguars prediction on Week 7 game

By Deniss Novickis | Published: October 17, 2025

Wembley Stadium hosts the third and final 2025 international game in London, as the Los Angeles Rams clash with the Jacksonville Jaguars in the Week 7 NFL matchup. Both teams have a 4-2 record so far, and both will have a bye in Week 8. Therefore, they might play it safe rather than sorry, not risking players with slight injuries and giving them a proper 3-week rest.

In this article, we'll check the odds for most favoured betting lines, analyse team form, squad news, and injury reports, and give a prediction on the outcome of this much-anticipated game.

Moneyline, spread, and total are three of the most popular markets among NFL bettors. While many players focus exclusively on a single one, such as wagering each week on the moneyline, we are always trying to find the most valuable spots for you. Let's take a look at the latest odds ahead of the upcoming battle in the capital of Great Britain.

Rams vs Jaguars moneyline

The Rams are favourites, but the odds on Sean McVay's team are going up, as the Californian outfit opened at around 1.50. The reason for that is the ankle injury suffered by Puka Nacua. The NFL leader in receptions has 616 receiving yards over the first six games, but he is highly likely to be a spectator on Sunday. While the Jaguars have their own squad problems, none of their injured players are as valuable as Nacua.

Rams vs Jaguars spread

The spread for the upcoming game is three points only, which indicates that the bookmakers give a slight edge to the Rams. While this might come out as a good option, it looks as though there's not much value in choosing this betting market for the match in London.

Rams vs Jaguars total

The total line for this match is 44.5 points, which is far more interesting. In six Rams' games this season, the total of 44.5 points was beaten four times, while it's three overs and three unders in six games by the Jaguars. The total here is fairly low, as the Rams are very ineffective in the red zone, often settling for field goals, while the Jaguars already made dozens of messy offensive plays that limited their scoring.

Los Angeles Rams

The Rams suffered a major blow in Week 6, losing their talismanic receiver Nacua. He is almost certain to miss the game against the Jaguars, so Davante Adams will step in as the go-to wide receiver, while Tutu Atwell will be the second choice for Matthew Stafford.

The latter leads the league in passing yards, and while Nacua was always his target man, Adams is very much used to this role, too. The Rams' defence is ranked third in the league, allowing only 18.3 points per game, and they have everything to stop the Jaguars, who are very sloppy offensively. All in all, the formal away team are reasoned favourites, as they have almost all the pieces of the puzzle to make another deep run in the playoffs.

Jacksonville Jaguars

The Jaguars already have as many wins as they did during the whole previous campaign. Liam Coen is doing great in the first season as the head coach, but let's be real - you can't build a contender overnight. Two linebackers and two tight ends are missing, but it's not the end of the world.

Jacksonville must improve in protecting quarterback Trevor Lawrence, who's constantly under pressure. This results in penalties, bad passes and turnovers. On the bright side, the Jaguars lead the league in turnover differential at +8. The team is first in interceptions (10), and Devin Lloyd has four of them, along with one fumble recovery. If the Jaguars can keep the ball safe and force a couple of turnovers from the Rams, that will be a huge boost to their chances of winning.

If we imagine the opponents playing 10 games against each other, there's no doubt that the Rams would come on top more often than not. It's a much more complete team with more keys to victory. However, their lack of stability in the red zone is a huge problem, and Nacua's injury will not help the matter. They should win in London, but in terms of betting, playing under 44.5 points at 1.90 looks much more promising than choosing the winner of this game.

Prediction: Rams 24, Jaguars 13

Betting on Rams' player props is another option here. Kyren Williams to score a touchdown at 1.71 looks very attractive, given he had three in the last two games. The Rams hand the ball to the running back on half of their plays in the red zone, so he should score again this time. Another prop to look at is Davante Adams having 6+ receptions at 1.55. The six-time Pro Bowl participant will have plenty of chances to add to his 396 yards over the first 6 weeks. This 2-leg parlay with the tasty odds of 2.65 is destined for success.

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