Liverpool vs Atletico Madrid prediction 17.09.2025 | Champions League

Many pundits thought that Liverpool would struggle after Jürgen Klopp left about two years ago, but things have actually got better. Salah and Co won the Premier League title with 84 points last season, and are favourites to win it again this season.

Arne Slot’s men are currently the only team with a 100% record in the English top flight after four games this season, and have also kept two clean sheets.

They achieved this without their record signing, Alexander Isak, who the boss has promised will play a part in Wednesday’s game.

Stefan Bajčetić and Rhys Williams will be unavailable for Liverpool this week due to injury, while Federico Chiesa was not included in the Champions League squad.

Meanwhile, Atlético Madrid look to have gone out of the title race in Spain's top flight after only four matches. Los Colchoneros picked up what was only their first win of the season in a 2:0 win over Villarreal last weekend.

As has been the case all season, Diego Simeone’s team scored first, but this time they held on to their lead and scored a second goal just after half-time.

With the previous two games being draws, Atletico have now avoided defeat in each of their last three games, but their fans will be concerned about their away record.

Los Colchoneros boast just one win from their last six away games and also lost their last two visits to Anfield. Another worry for the visitors is the absence of José María Giménez who has been dealing with a hamstring injury since June.