Lille vs Lyon prediction 28.09.2025 | Ligue 1

Lille enter this match on the back of a steady run of results, showing resilience even when not at their sparkling best. They head into this game on the back of a 2-1 over Brann in the Europa League season opener and should be in good spirit. However, consistency in attack has been a concern, with the team occasionally struggling to convert possession into goals, although a 7-1 thrashing of Lorient a couple of weeks ago have racked up their goal tally up to 13. 

Injury-wise, Lille are monitoring a few key players, but the majority of the squad is expected to be available for selection. Toure, Meunier, Caillard and Ribeiro are listed as unavailable according to some sources. Their midfield dynamism and quick transitions remain their main weapon, and playing at home should give them the confidence to take the game to Lyon.

Lyon arrive in Lille with momentum after yet another win this season - they picked up a 1-0 win over FC Utrecht in the Europa League opener on Thursday. They are currently in a four-horse race for the Ligue 1 title together with AS Monaco, PSG and surprisingly Strasbourg. A perfect home record - with three wins out of a possible three - is what makes them stand out, but they did fall short in the game against Rennes before the international break, losing 3-1. The visitors’ creativity in midfield has been a driving force, helping them dominate possession and create chances. 

Injury wise, they only have a couple of players listed as doubtful ahead of this game: Abner Vinicius and Remy Descamps are not 100 percent fit. Lyon’s firepower and ability to break quickly on the counter means they will remain a dangerous opponent throughout the 90 minutes.