Cagliari vs Pisa prediction 21.12.2025 | Serie A

Cagliari return to Unipol Domus looking to bounce back from a narrow 2:1 defeat against Atalanta last weekend. Gianluca Scamacca bagged a brace as La Dea edged to victory in Bergamo. 

Fabio Pisacane´s men have endured a tough run of results in the past couple of months, failing to win all but one of their last 12 games. Cagliari did claim a vital 1:0 win against Roma in their most recent game at Unipol Domus after a thrilling 3:3 draw against Genoa at the end of November. The Sardinians now sit 15th in Serie A, only two points above the drop zone. 

Three of Cagliari´s last four games finished with over 2.5 goals, and another entertaining fixture could be on the cards with Pisa´s road matches averaging over three goals per game.

Head coach Pisacane has a handful of absentees this weekend. Andrea Belotti, Zé Pedro, Mattia Felici, Gennaro Borrelli and Yerry Mina are all unavailable.

Pisa hit the road still searching for their first points in December. Alberto Gilardino´s side failed to score while losing each of their last three games, including a 1:0 defeat at Lecce last weekend.

I Nerazzurri have struggled to find much form since their return to Serie A in August. Pisa failed to win 14 of 15 Serie A games, and now sit second bottom of the division, with just ten points on the board.

On the ross, Gillardino´s men have proven an entertaining side to watch this season. I Torri saw 24 goals scored in just seven away Serie A fixtures.

The visitors come into this fixture with three players unavailable. Calvin Stengs and Juan Cuadrado remain sidelined. M’Bala Nzola is suspended and will miss out.