Napoli vs Pisa prediction 22.09.2025 | Serie A
Napoli
3 - 2
Elapsed: FT
Half time: 1 - 0
Full time: 3 - 2
Kick off:
Date:
Pisa
1
1.32
X
5.46
2
11.10
The match has ended, you can view today's football predictions and football predictions for tomorrow.
Contents
- Competition: Serie A
- Date: 22nd September, 2025
- Kickoff: 19:45 UK / 20:45 CEST
- Venue: Stadio Diego Armando Maradona
The reigning Serie A champions Napoli have made a blistering start to their title defence in the 2025/26 season, winning each of their first three matches. They will look to extend their perfect run this weekend when they host newly promoted Pisa at the Stadio Diego Armando Maradona. The visitors are still searching for their first win in Italy’s top flight.
Napoli vs Pisa Head to Head (H2H) stats
-
Napoli
3 : 1
Pisa
Coppa Italia
Napoli team overview
Napoli could hardly have asked for a better start to the campaign. Antonio Conte’s men have taken maximum points so far and sit joint-top of the Serie A table alongside Juventus, both on nine points. Gli Azzurri opened their season with a 2-0 victory over Sassuolo, followed by a narrow 1-0 home win against Cagliari. They then impressed with a 3-1 away triumph at Fiorentina before the international break.
With new arrivals such as Kevin De Bruyne, Napoli have become one of the most creative sides in the league, averaging 3.3 big chances per game. However, finishing has been their weak spot - they have failed to convert two out of every three of those clear opportunities.
Romelu Lukaku and goalkeeper Alex Meret are ruled out for Sunday’s match, while Amir Rrahmani also remains sidelined.
Last matches of Napoli
-
Manchester City
2 : 0
Napoli
Champions League
-
Fiorentina
1 : 3
Napoli
Serie A
-
Napoli
1 : 0
Cagliari
Serie A
-
Sassuolo
0 : 2
Napoli
Serie A
-
Napoli
2 : 1
Olympiacos Piraeus
Club Friendlies 3
Napoli lineup
Goalkeeper
-
97
Alex Meret
Defenders
-
22
Giovanni Di Lorenzo
-
31
Sam Beukema
-
4
Alessandro Buongiorno
-
37
Leonardo Spinazzola
Midfielders
-
68
Stanislav Lobotka
-
99
Frank Anguissa
-
11
Kevin De Bruyne
-
21
Matteo Politano
-
8
Scott McTominay
Forwards
-
19
Rasmus Højlund
Pisa team overview
For Pisa, life in Serie A has been far less comfortable. Alberto Gilardino’s side began positively with a 1-1 draw away at Atalanta, but they have since fallen to back-to-back 1-0 home defeats against Roma and Udinese. That leaves Pisa among six teams still without a victory this season.
Their main issue has been in front of goal. Despite averaging 1.7 big chances per game, they have yet to convert a single one. Without a cutting edge, turning performances into points has been a major challenge.
Pisa do not have an injury crisis, though Juan Cuadrado is a doubt due to a thigh problem.
Last matches of Pisa
-
Pisa
0 : 1
Udinese
Serie A
-
Pisa
0 : 1
AS Roma
Serie A
-
Atalanta
1 : 1
Pisa
Serie A
-
Bayer Leverkusen
3 : 0
Pisa
Club Friendlies 3
-
Pisa
2 : 1
Cremonese
Serie B
Pisa lineup
Goalkeeper
-
1
Adrian Šemper
Defenders
-
5
Simone Canestrelli
-
4
Antonio Caracciolo
-
47
Mateus Lusuardi
-
3
Samuele Angori
-
15
Idrissa Touré
Midfielders
-
14
Ebenezer Akinsanmiro
-
20
Michel Aebischer
-
10
Matteo Tramoni
-
32
Stefano Moreo
Forwards
-
9
Henrik Wendel Meister
Prediction
Napoli, with their quality and depth, will be expected to control the game and create opportunities, as they have in their opening fixtures. However, their conversion struggles, combined with Pisa’s cautious approach, suggest goals may be at a premium.
Only one of Napoli’s first three Serie A matches has gone over 2.5 goals, while all three of Pisa’s games have finished under that mark. With Napoli also coming off a midweek Champions League outing, fatigue could further temper their attacking output.
Prediction: Under 2.5 goals
Three reasons we expect Under 2.5 Goals
- Two of Napoli’s three Serie A victories have finished with under 2.5 goals.
- All three of Pisa’s matches this season have also ended under the 2.5 line.
- In midweek Champions League action, Manchester City managed only two goals against Napoli, despite the Italians playing with 10 men for over an hour.
Main prediction Napoli - Pisa
Under 2.5 goals
Best Odds:
22bet
1.95
Napoli vs Pisa standings in Serie A
| Regular Season | P | W | D | L |
G - A
|
GD | Pts | |
|---|---|---|---|---|---|---|---|---|
| 1 | Napoli | 4 | 4 | 0 | 0 | 9 - 3 | +6 | 12 |
| 2 | Juventus | 4 | 3 | 1 | 0 | 8 - 4 | +4 | 10 |
| 3 | Milan | 4 | 3 | 0 | 1 | 7 - 2 | +5 | 9 |
| 4 | Roma | 4 | 3 | 0 | 1 | 3 - 1 | +2 | 9 |
| 5 | Atalanta | 4 | 2 | 2 | 0 | 9 - 3 | +6 | 8 |
| 6 | Cremonese | 4 | 2 | 2 | 0 | 5 - 3 | +2 | 8 |
| 7 | Cagliari | 4 | 2 | 1 | 1 | 5 - 3 | +2 | 7 |
| 8 | Como | 4 | 2 | 1 | 1 | 5 - 3 | +2 | 7 |
| 9 | Udinese | 4 | 2 | 1 | 1 | 4 - 5 | -1 | 7 |
| 10 | Inter | 4 | 2 | 0 | 2 | 11 - 7 | +4 | 6 |
| 11 | Bologna | 4 | 2 | 0 | 2 | 3 - 3 | 0 | 6 |
| 12 | Torino | 4 | 1 | 1 | 2 | 1 - 8 | -7 | 4 |
| 13 | Lazio | 4 | 1 | 0 | 3 | 4 - 4 | 0 | 3 |
| 14 | Sassuolo | 4 | 1 | 0 | 3 | 4 - 7 | -3 | 3 |
| 15 | Hellas Verona | 4 | 0 | 3 | 1 | 2 - 6 | -4 | 3 |
| 16 | Genoa | 4 | 0 | 2 | 2 | 2 - 4 | -2 | 2 |
| 17 | Fiorentina | 4 | 0 | 2 | 2 | 3 - 6 | -3 | 2 |
| 18 | Parma | 4 | 0 | 2 | 2 | 1 - 5 | -4 | 2 |
| 19 | Pisa | 4 | 0 | 1 | 3 | 3 - 6 | -3 | 1 |
| 20 | Lecce | 4 | 0 | 1 | 3 | 2 - 8 | -6 | 1 |