Home Bookmakers Tips Bonuses

Lazio vs AC Milan Prediction 04.12.2025 | Coppa Italia

Kick off:

Date:

1

3.30

X

3.10

2

2.25

  • Competition: Coppa Italia - Round of 16
  • Date: Thursday, 4th, December 2025
  • Kickoff: 20:00 UK / 21:00 CET
  • Venue: Stadio Olimpico (Rome)

The fiercest Round of 16 clash in the Coppa Italia is set for Wednesday night at the Stadio Olimpico, where SS Lazio and AC Milan will battle for a place in the quarterfinals.

vs Head to Head (H2H) stats

  1. AC Milan

    1 : 0

    Lazio

    Serie A

  2. AC Milan

    1 : 2

    Lazio

    Serie A

  3. Lazio

    2 : 2

    AC Milan

    Serie A

  4. Lazio

    0 : 1

    AC Milan

    Serie A

  5. AC Milan

    2 : 0

    Lazio

    Serie A

  6. AC Milan

    2 : 0

    Lazio

    Serie A

Across 193 historical matchups, AC Milan have dominated the series with 87 wins, compared to 41 victories for SS Lazio, with the other 65 contests concluding all square.

Lazio team overview

Throughout Coppa Italia history, SS Lazio have enjoyed the luxury of lifting this prestigious national trophy on seven occasions, though it has been seven years since their last triumph, a 2-0 victory over Atalanta in the final.

Since then, the Biancocelesti have struggled to make a significant impact in the competition, reaching the final four just once in 2023-24. Nevertheless, their record of navigating the opening round smoothly in 14 consecutive editions offers a measure of optimism ahead of their challenging clash with AC Milan.

That said, it is fair to observe that Lazio have not been performing at an elite level for some time. They have struggled to maintain consistency, with just four wins in their last ten outings raising doubts over their ability to avoid an early exit — a fate last experienced in the 2004-05 season.

Complicating matters further for the Rome-based side is the absence of several key players. Midfield duo Nicolo Rovella and Danilo Cataldi will be unavailable, while experienced centre-back Samuel Gigot is also sidelined due to injury, presenting additional challenges in Wednesday’s high-stakes encounter.

Last matches of

  1. AC Milan

    1 : 0

    Lazio

    Serie A

  2. Lazio

    2 : 0

    Lecce

    Serie A

  3. Inter Milan

    2 : 0

    Lazio

    Serie A

  4. Lazio

    2 : 0

    Cagliari

    Serie A

  5. Pisa

    0 : 0

    Lazio

    Serie A

lineup

Goalkeeper

  • 35

    Christos Mandas

Defenders

  • 17

    Nuno Tavares

  • 13

    Alessio Romagnoli

  • 4

    Patric

  • 29

    Manuel Lazzari

Midfielders

  • 26

    Toma Bašić

  • 21

    Reda Belahyane

  • 8

    Mattéo Guendouzi

Forwards

  • 10

    Mattia Zaccagni

  • 14

    Tijjani Noslin

  • 9

    Pedro

AC Milan team overview

At the opposite end of the Olimpico, AC Milan will take the stage — a club historically steeped in Coppa Italia tradition, ranking third in all-time final appearances. Yet, only a third of those finals have ended in triumph, with their last trophy coming all the way back in 2003, marking a prolonged drought for a team of such stature.

One of their recent disappointments came as recently as last season, when Bologna edged them out with a solitary goal, leaving the Rossoneri eager to make a deep run in this year’s tournament, especially as their focus this season has been largely confined to domestic league competition.

Due to last season’s modest eighth-place finish in Serie A, Milan were required to start their Coppa Italia campaign from the very first round. Fortunately, they navigated their opening ties smoothly, defeating Bari 2-0 before dispatching Lecce with three goals without reply.

Under Massimiliano Allegri, who took charge at the start of the 2025-26 season, Milan have been in imperious form, remaining unbeaten since August 28 — a span covering 13 matches, including nine victories.

In terms of absences for the third round, young right-back Zachary Athekame and top scorer Christian Pulisic will miss the midweek fixture due to fitness concerns, leaving Allegri to adjust his lineup accordingly.

Last matches of

  1. AC Milan

    1 : 0

    Lazio

    Serie A

  2. Inter Milan

    0 : 1

    AC Milan

    Serie A

  3. Parma

    2 : 2

    AC Milan

    Serie A

  4. AC Milan

    1 : 0

    AS Roma

    Serie A

  5. Atalanta

    1 : 1

    AC Milan

    Serie A

lineup

Goalkeeper

  • 16

    Mike Maignan

Defenders

  • 31

    Strahinja Pavlović

  • 46

    Matteo Gabbia

  • 23

    Fikayo Tomori

Midfielders

  • 2

    Pervis Estupiñán

  • 12

    Adrien Rabiot

  • 14

    Luka Modrić

  • 4

    Samuele Ricci

  • 56

    Alexis Saelemaekers

Forwards

  • 10

    Rafael Leão

  • 18

    Christopher Nkunku

Prediction

The Rossoneri arrive in the Italian capital with a clear psychological edge, having secured a 1-0 victory over Lazio a few days ago, powered by Rafael Leão. This result not only underlined their excellent form but also allowed them to maintain their lead at the top of the Serie A table.

Given the tactical profile of both sides, a similar pattern is expected in this marquee matchup — a disciplined, defense-focused encounter where margins will be slim. Both teams have recently demonstrated consistent defensive solidity, frequently keeping opponents off the scoresheet.

For Milan, Lazio joins a list of recent 1-0 victims, including Inter and AS Roma, indicating that this fixture could once more be settled by a single goal or potentially end in a goalless stalemate during regulation time.

Four Reasons we expect Under 2.5 Goals

  1. Seven consecutive Lazio matches have featured no more than two goals.
  2. Lazio’s defense has been breached in only two of their last seven games.
  3. AC Milan’s last three victories were all secured with a 1-0 scoreline against Roma, Inter, and Lazio.
  4. Four of AC Milan’s last five matches have ended with under 2.5 goals.

Main prediction -

Under 2.5 goals

Updated

clock
winrate

58% winrate

wins

3 wins in a row

don_andres is the professional football and basketball tipster who can give you deep analytic for each match 

Best Odds:

Melbet

1.67

Bet here

Lazio vs AC Milan – FAQ

? Who is Lazio's player to watch?

With seven goals and two assists to his name, Christian Pulisic is AC Milan’s top scorer.

? Who is AC Milan's player to watch?

Taty Castellanos is Lazio’s modest top scorer this season with two goals and three assists.