Bayer Leverkusen vs Mainz prediction 28.02.2026 | Bundesliga

Leverkusen have enjoyed a strong season overall, currently 12-3-7 with 39 points after 22 matches. Their attack has been lightened by forward Patrik Schick, who leads the team’s scoring with 7 Bundesliga goals this season, while Alejandro Grimaldo (defender) has also contributed with 5 goals and high assist numbers. 

In midweek, Leverkusen advanced to the round of 16 of the Champions League after successfully defending their 2-0 first-leg lead against Olympiacos, as their second-leg encounter at the BayArena ended goalless. In Bundesliga matters, Kasper Hjulmand’s men were unable to extend their four-game unbeaten league streak, stumbling against Union Berlin last weekend with a 1-0 defeat.

Despite strong attacking statistics, Leverkusen’s squad depth is being tested by injuries. Key defender Loïc Badé is sidelined with a thigh injury, and there are doubts over forward Malik Tillman’s participation due to an ankle issue. Additionally, goalkeeper Mark Flekken, winger Nathan Tella, and attacker Eliesse Ben Seghir are ruled out or doubtful ahead of the fixture.

Mainz’s season began poorly, prompting the appointment of Urs Fischer as manager in December 2025. Under his guidance, the club showed signs of resurgence, picking up 10 points from their last five Bundesliga outings and achieving a notable 2-1 away win against RB Leipzig - only their second away victory in the league this season. However, their form has stalled over the past couple of weeks, with a heavy 4-0 away defeat to Borussia Dortmund followed by a 1-1 draw with HSV on the last matchday, ending Mainz’s three-game winning streak in the Bundesliga.

Injury and availability concerns could hinder Mainz’s performance. Several squad members are unavailable or doubtful, including Stefan Bell (knee), Anthony Caci (hamstring), Andreas Hanche-Olsen (muscle), Benedict Hollerbach (Achilles), and goalkeeper Robin Zentner (groin). Additionally, Nelson Weiper and Fabio Moreno Fell have missed recent matches due to illness. These absences weaken depth, particularly in defence and attack.